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KMID : 0043320140370010043
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Archives of Pharmacal Research
2014 Volume.37 No. 1 p.43 ~ p.52
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Carbon-based drug delivery carriers for cancer therapy
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Lim Dong-Jin
Sim Myeong-Bu
Oh Lee-Seul
Lim Kyung-Hee
Park Han-Soo
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Abstract
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In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug solubility, an ability to reduce systemic toxicity through specific-tumor targeting, and rapid clearance. In this regard, carbon allotropes such as graphene oxide (GOs), carbon nanotubes (CNTs), and nanodiamonds (NDs), have been investigated, as they possess sufficient surface-to-volume ratio, thermal conductivity, rigid structural properties capable of post-chemical modification, and excellent biocompatibility. This review is aimed at exploring these carbon-based nanomaterials for use as multifaceted cancer drug carriers and is intended to demonstrate that GOs, CNTs, and NDs are likely to improve chemotherapeutical strategy for cancers in either a sole or combinational manner.
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KEYWORD
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Nanodiamonds, Graphene oxide, Carbon nanotube, Drug delivery
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